WorldPosted at: Apr 29 2025 6:15PM


Australian researchers advance genetic tools to better predict inherited cancer risk

Sydney, Apr 29 (UNI) Medical researchers have developed advanced computational tools that significantly improve the accuracy of genetic testing for inherited cancer risk, an Australian government research institute has revealed.
The accuracy of genetic testing has been significantly improved particularly in people with Li-Fraumeni Syndrome, a rare, inherited cancer predisposition syndrome caused by faults in the TP53 gene, which significantly increases the risk of developing multiple types of cancer, according to a news release of the QIMR Berghofer (formerly the Queensland Institute of Medical Research) on Monday.
The study by researchers at QIMR Berghofer, collaborating with Spain's Hospital Clinico San Carlos and US--based Ambry Genetics, shows how integrating new computer-based predictions with existing genetic models enhances the classification of genetic variants, helping distinguish between harmless mutations and those likely to cause cancer.
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